APPLICATION OF BEAD ARRAY TECHNOLOGY TO SIMULTANEOUS DETECTION OF HUMAN LEUCOCYTE ANTIGEN AND HUMAN PLATELET ANTIGEN ANTIBODIES

Human platelet antigen polymorphism in bronchial asthma

Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...

Human Leucocyte Antigen Matching Strategy

Antibodies against human platelet alloantigens and human leucocyte antigen class 1 in Saudi Arabian multiparous women and multi-transfused patients

OBJECTIVES To determine the frequency of alloimmunization against human platelet antigens (HPAs) and human leucocyte antigen class 1 (HLA1) in multiparous women and multi-transfused patients.   METHODS This prospective study was conducted between January and August 2013, on 50 multiparous women with no history of previous blood transfusion recruited from the Obstetrics and Gynecology Clinic, ...

The human leucocyte antigen (HLA) system.

Since the discovery of the HLA system, over 40 years ago, we now have an understanding of the role of HLA molecules in the adaptive immune response, as well as in the alloimmune response experienced when foreign HLA is introduced into an individual via transplant, transfusion or pregnancy. Retrospective studies in the 1970s and 1980s illustrated the importance of matching for HLA antigens in tr...

P-145: Role of Human Leukocyte Antigen in Miscarriage

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...